How is GABA related to my Anxiety? Gamma-aminobutyric acid (GABA) is a neurotransmitter within the body that is widely distributed throughout the central nervous system. GABA acts as the major inhibitory neurotransmitter in the brain.
Relevance of GABA to Anxiety and Mental Health
Low GABA levels are associated with a range of conditions affecting the nervous system, including anxiety, depression, insomnia, epilepsy, panic attacks and PTSD.
In these conditions, GABA-alpha receptor deficits have been found in some parts of the brain. Similarly, it has been found that people with depression exhibit decreased brain concentrations of GABA and alterations in GABA alpha receptors.
Synthesis of GABA
GABA is synthesised in tissues in the body from glutamic acid via the enzyme glutamic acid decarboxylase, with pyridoxal-5-phosphate (P5P) acting as a cofactor. P5P is the activated form of vitamin B6.
Outside of the central nervous system, GABA is sy...